{"product_id":"abcam-ab236590","title":"Abcam, ab236590, Anti-CAP2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal CAP2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Adenylyl cyclase-associated protein 2 aa 200 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Adenylyl cyclase-associated protein 2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P40123\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCAP2 also known as Cyclase Associated Protein 2 is a protein playing an essential role in actin dynamics. It has a molecular mass of approximately 54 kDa. Researchers have detected its expression in various tissues including the heart skeletal muscle and brain. CAP2 influences the organization of the cytoskeleton by binding to actin filaments and regulating their polymerization and depolymerization. Its activity makes it an important player in cell motility and structure maintenance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCAP2 contributes to cellular processes by modulating actin filament turnover and facilitating actin recycling. It operates as part of a protein complex that includes other actin-binding proteins often working in tandem with profilin and cofilin. This complex formation is integral to the regulation of cytoskeletal organization impacting important cellular functions like cell division intracellular transport and signal transduction.\u003cbr\u003e\nPathways\u003cbr\u003e\nCAP2 is an active participant in pathways controlling cell movement and structural integrity particularly the actin cytoskeleton signaling pathway. In this role CAP2 interacts with proteins such as cofilin which also modulates actin dynamics to maintain a balance of actin filament assembly and disassembly. Another pathway CAP2 is involved in is the cell adhesion pathway where it helps facilitate the dynamic remodeling necessary for cell attachment and migration.\u003cbr\u003e\nCAP2 has been linked to cardiac diseases and cancer. Alterations in CAP2 expression have been associated with the development of dilated cardiomyopathy a condition marked by weakened heart muscle functionality. Furthermore CAP2 has demonstrated interactions with p53 a protein often mutated in cancers implicating it in processes that may contribute to tumor growth and metastasis. These connections reveal its importance not only in normal cellular function but also in pathological states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854364496041,"sku":"ab236590","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab236590","provider":"Iright","version":"1.0","type":"link"}