{"product_id":"abcam-ab236617","title":"Abcam, ab236617, Anti-GNA12 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GNA12 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Guanine nucleotide-binding protein subunit alpha-12 aa 100-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Guanine nucleotide-binding protein subunit alpha-12 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.Q03113\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGNA12 also known as Gα12 is a member of the G protein family. This protein roughly weighs 44 kDa. It is part of the larger family of heterotrimeric G proteins which consist of alpha beta and gamma subunits. GNA12 is present in various tissues throughout the body including the heart lungs and thymus. GNA12 plays a mechanical role by acting as a molecular switch inside cells transmitting signals from activated receptors to target molecules which changes their activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGNA12 regulates cell signaling processes involving growth differentiation and movement. It operates within the G12\/G13 class of G protein signaling pathways and sometimes it works forming a complex with other proteins. It has been implicated in cellular interactions with the cytoskeleton and affects the organization of actin filaments. These actions influence the control of cell shape and motility suggesting a role in cellular migration and adhesion phenomena.\u003cbr\u003e\nPathways\u003cbr\u003e\nGNA12 participates in the Rho family of GTPases signaling pathway and the MAPK\/ERK pathway both important for cellular response and adaptation. Within these pathways GNA12 activates the Rho guanine nucleotide exchange factors which then influences Rho-dependent processes. It also interacts with other proteins such as GNA13 and RHOA linking it to signal transduction mechanisms that modulate various cellular outcomes including growth and differentiation.\u003cbr\u003e\nGNA12 links to cancer and pulmonary hypertension. Its role in cancer relates to its influence on cell migration and invasion which are processes involved in cancer metastasis. Studies have shown that changes in GNA12's function can contribute to oncogenic transformation. In pulmonary hypertension altered GNA12 signaling may disrupt normal vascular smooth muscle function contributing to disease progression. The protein connects with RhoA and MAPK\/ERK pathway components in these contexts indicating its involvement in the pathology of these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854147965097,"sku":"ab236617","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab236617","provider":"Iright","version":"1.0","type":"link"}