{"product_id":"abcam-ab237053","title":"Abcam, ab237053, Anti-Myozenin 2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Myozenin 2 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYOZ2 aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MYOZ2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9NPC6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMyozenin 2 also known as calsarcin-1 mechanically functions as a scaffold protein that anchors filamentous actin to the sarcomeric Z-disc in striated muscles. It weighs approximately 32 kDa. Myozenin 2 is primarily expressed in cardiac and skeletal muscle tissues where it plays an important role in maintaining the structural integrity of muscle fibers. Its interaction with other proteins at the Z-disc is important for muscle function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMyozenin 2 contributes to the regulation of muscle contraction and signal transduction within muscle cells. It forms part of a multiprotein complex at the Z-disc where it interfaces with proteins such as telethonin and myotilin. This positioning aids in the transmission of mechanical and signaling information necessary for muscle adaptation and maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nMyozenin 2 has roles in the regulation of muscle hypertrophy and myopathy pathways. This protein interacts closely with calcineurin a phosphatase involved in calcium-dependent signaling pathways that regulate muscle growth and differentiation. Additionally Myozenin 2 can affect protein kinase C pathways which are essential for modulating the cellular responses to mechanical stress in muscle tissues.\u003cbr\u003e\nMyozenin 2 is linked to conditions such as familial hypertrophic cardiomyopathy and muscular dystrophy. Changes in the expression or function of Myozenin 2 can lead to disrupted Z-disc integrity and impaired muscle function. In cardiomyopathy Myozenin 2's interaction with calcineurin becomes relevant as alterations in this interaction may contribute to the pathogenesis. In muscular dystrophy its relationship with telethonin becomes significant influencing the structural stability of muscle cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854081839273,"sku":"ab237053","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab237053","provider":"Iright","version":"1.0","type":"link"}