{"product_id":"abcam-ab237490","title":"Abcam, ab237490, Anti-ZBTB8OS antibody","description":"\u003cp\u003eSize: 100µg \/ 100µL\u003cbr\u003e\nRabbit Polyclonal ZBTB8OS antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZBTB8OS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human ZBTB8OS.Q8IWT0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZBTB8OS also known as Zinc Finger and BTB Domain Containing 8 is a zinc finger protein with a molecular weight of approximately 56 kDa. This protein localizes predominantly to the nucleus. Expression of ZBTB8OS occurs in various tissues but higher levels can be observed in immune-related tissues such as spleen and peripheral blood leukocytes. Also its expression is documented in certain cancer cell lines suggesting a possible involvement in cellular regulation mechanisms.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZBTB8OS functions as a transcriptional regulator. It acts within the cell by binding DNA and influencing gene expression. While it may not be widely known to be a part of a larger complex studies suggest it interacts with other regulatory proteins to modulate transcription. This suggests that ZBTB8OS might play an important role in regulating genes involved in cell cycle progression and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nZBTB8OS influences gene networks related to cellular proliferation and immune responses. It intersects with pathways such as MAPK signaling and may impact NF-kB mediated transcriptional activity. The protein shows interactions with other transcription factors and its regulation might be connected to proteins such as p53 an important factor in cell cycle control and apoptosis.\u003cbr\u003e\nZBTB8OS has been linked to certain cancers and immune dysfunctions. Altered expression of ZBTB8OS is observed in conditions such as leukemia suggesting its potential role in tumorigenesis. Additionally through its regulatory network it could potentially connect with other proteins like c-Myc which is also implicated in cancer progression. Understanding these interactions offers insights into therapeutic targets for related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854223003817,"sku":"ab237490","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab237490","provider":"Iright","version":"1.0","type":"link"}