{"product_id":"abcam-ab237527","title":"Abcam, ab237527, Anti-SLC20A1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SLC20A1 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC20A1 aa 250-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SLC20A1 aa 250-500. The exact immunogen used to generate this antibody is proprietary information.Q8WUM9\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLC20A1 also known as PiT-1 is a type III sodium-dependent phosphate transporter with a molecular mass of approximately 75 kDa. It helps in the uptake of inorganic phosphate into cells using sodium as a co-transport mechanism. This transport is essential for maintaining phosphate homeostasis within the body. SLC20A1 is expressed in various tissues including the liver kidney lung and cardiac tissues indicating its broad role in bodily functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe expression of SLC20A1 plays a role in phosphate metabolism contributing to bone mineralization and cellular energy transfer. It exists as part of a complex that regulates phosphate uptake alongside its relative SLC20A2. The protein is key to cellular proliferation and survival and it influences processes like cell signaling and metabolism through its transport activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nPhosphate modulation by SLC20A1 interacts with cellular pathways involving calcium signaling and energy production. It is also associated with the mTOR pathway which controls cell growth and proliferation. Alongside proteins like PiT-2 SLC20A1 regulates phosphate balance which is essential for proper cellular function linking it to broader metabolic pathways.\u003cbr\u003e\nMutations or dysregulation of the SLC20A1 gene connect to conditions such as familial idiopathic basal ganglia calcification and hyperphosphatemia. These conditions often involve abnormal phosphate deposition in body tissues. Abnormal interactions with proteins like SCL20A2 might lead to defective phosphate uptake resulting in disease manifestations affecting neurological and renal functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854134956201,"sku":"ab237527","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab237527","provider":"Iright","version":"1.0","type":"link"}