{"product_id":"abcam-ab237618","title":"Abcam, ab237618, Anti-SorCS1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SorCS1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SORCS1 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SORCS1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q8WY21\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSorCS1 also known as Sortilin-related Vps10 domain containing receptor 1 is a multifunctional protein with a mass of approximately 130 kDa. The protein primarily operates as a sorting receptor within cells influencing protein trafficking. It can bind neurotrophins regulate their transport and manage degradation pathways. SorCS1 is expressed in various tissues including the central nervous system muscle and pancreas. Notably it functions on the cell surface but is also present in distinct intracellular compartments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein impacts neuronal development and glucose metabolism. SorCS1 belongs to the Vps10p domain receptor family which partakes in protein sorting processes. It is involved in amyloid-beta metabolism and modulates insulin receptor signaling. Through these interactions SorCS1 indirectly affects energy balance and brain function making it significant for neural cell maintenance and metabolic regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nSorCS1 interacts with cellular mechanisms like insulin signaling and amyloid-beta processing. It modulates the insulin signaling pathway by interacting with the insulin receptor. SorCS1 also influences the amyloid precursor protein (APP) processing pathway impacting the production of amyloid-beta. These pathways link SorCS1 functionally to proteins like sortilin and low-density lipoprotein receptor-related protein 1 (LRP1) highlighting its role in intersecting signaling mechanisms.\u003cbr\u003e\nResearch indicates SorCS1's connection to diabetes and Alzheimer's disease. It can influence the development of type 2 diabetes by modulating insulin signaling pathways and impacting glucose homeostasis. SorCS1 affects the accumulation of amyloid-beta peptides an important factor in Alzheimer's disease progression. SorCS1’s relationships with proteins such as APP and LRP1 deepen its relevance to these conditions presenting it as a potential therapeutic target for intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854230278313,"sku":"ab237618","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab237618","provider":"Iright","version":"1.0","type":"link"}