{"product_id":"abcam-ab237807","title":"Abcam, ab237807, Anti-14-3-3 alpha + beta antibody","description":"\u003cp\u003eSize: 100µg \/ 100µL\u003cbr\u003e\nRabbit Polyclonal 1433B phospho S184 + S186 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse, Rat, Zebrafish samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human YWHAB phospho S184 + S186.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human, Zebrafish,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human YWHAB phospho S184 + S186.P31946\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\n14-3-3 alpha + beta proteins also known as YWHAZ (14-3-3 zeta) and YWHAB (14-3-3 beta) are part of a family of conserved proteins weighing approximately 28-33 kDa each. These proteins are found in many tissues and engage in binding phosphorylated serine\/threonine residues on their target molecules. This binding influences the activity localization and stability of these target proteins. Expression of 14-3-3 alpha + beta proteins is prominent in the brain where they participate in key signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\n14-3-3 proteins play central roles in regulating diverse cellular processes. These proteins frequently serve as scaffolding molecules stabilizing complexes for signal transduction pathways. By interacting with numerous partner proteins 14-3-3 complexes modulate cell cycle control apoptosis and DNA damage response. They help maintain cellular homeostasis by binding and regulating enzymes receptors and transcription factors.\u003cbr\u003e\nPathways\u003cbr\u003e\n14-3-3 proteins are integral to many signaling cascades. The MAPK\/ERK pathway involves these proteins with 14-3-3 binding to Raf kinases influencing signal transduction. They also participate in the PI3K\/Akt pathway where 14-3-3 interaction with Akt affects cell survival and growth. 14-3-3 proteins regulate various cellular functions by interacting with related kinases and phosphatases in these pathways.\u003cbr\u003e\nAlterations of 14-3-3 protein function have significant implications. Neurodegenerative disorders such as Alzheimer’s disease show changes in 14-3-3 protein binding patterns affecting neuronal stability. Aberrant 14-3-3 interactions also connect to cancerous pathways particularly in breast cancer where regulation of p53 and other tumor suppressor proteins becomes disrupted. 14-3-3 proteins influence disease progression through their extensive network of protein interactions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848604569769,"sku":"ab237807","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab237807","provider":"Iright","version":"1.0","type":"link"}