{"product_id":"abcam-ab23886","title":"Abcam, ab23886, Anti-KAT5 \/ Tip60 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal KAT5 \/ Tip60 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 30 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:ab23886 gives nuclear staining for Tip60 in interphase cells (see below), which is lost upon entry into mitosis (not shown). This signal can be successfully quenched using the immunizing peptide ab26349.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKAT5 also known as Tip60 is a histone acetyltransferase with a molecular mass of approximately 60 kDa. This enzyme plays an important mechanical role in regulating chromatin dynamics by acetylating lysine residues on histone tails which affects gene expression. It is also involved in non-histone protein acetylation influencing various signaling pathways. KAT5 is expressed across many tissues with higher levels observed in the brain heart and testis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKAT5 acetylates histones and participates in the regulation of transcription DNA repair and cell cycle progression. It is a critical component of the NuA4 complex which includes other important proteins like EP400 and TRRAP. Through its acetylation activity KAT5 affects chromatin structure thereby influencing gene expression involved in growth control apoptosis and DNA repair mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nKAT5 is integrally involved in processes such as the DNA damage response and apoptosis. Within these pathways KAT5 interacts with proteins like p53 which plays a significant role in maintaining genomic stability. KAT5-mediated acetylation modulates p53's activation and its ability to engage in apoptotic pathways as well as the cell's response to DNA damage.\u003cbr\u003e\nKAT5 has links to neurodegenerative disorders and cancer. Its dysregulation may contribute to the development of Alzheimer's disease through altered acetylation of tau protein; abnormalities in tau acetylation are implicated in this disorder. Similarly in cancer interactions with proteins like MYC suggest KAT5's involvement in oncogenic pathways. Changes in KAT5 expression or activity have been observed in certain cancers highlighting its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855815332009,"sku":"ab23886","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab23886","provider":"Iright","version":"1.0","type":"link"}