{"product_id":"abcam-ab238868","title":"Abcam, ab238868, Anti-GNG4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GNG4 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GNG4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human GNG4.P50150\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe G-protein gamma subunit 4 also known as GNG4 is a component of the heterotrimeric G-protein complex. It has a molecular mass of approximately 7.9 kDa. This protein is typically expressed in various tissues including the brain and spinal cord. Functionally GNG4 is involved in signal transduction processes by forming a complex with the G-protein beta subunit playing a critical role in transmitting signals from G-protein-coupled receptors (GPCRs) to downstream effectors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGNG4 participates in the modulation of intracellular signal pathways. It forms an integral part of the G-protein complex which includes another subunit known as GNB1. This complex is necessary for proper functioning of GPCR-mediated signaling. The G-protein complex influences various cellular responses by affecting ion channels enzymes and other intracellular pathways. The presence of GNG4 in neuronal tissues suggests its role in neurotransmission and the potential influence on neurologic function.\u003cbr\u003e\nPathways\u003cbr\u003e\nGNG4 plays a role in the adenylyl cyclase signaling pathway and the phospholipase C pathway. In both pathways GNG4 together with GNB1 regulates the conversion of extracellular signals into intracellular actions. These actions include cyclic AMP production or calcium ion release which subsequently affect cellular activities. This involvement links GNG4 to various cellular processes by mediating inputs from diverse signals through its interaction with GPCR-related pathways.\u003cbr\u003e\nGNG4 is associated with conditions such as neuropsychiatric disorders and cancer. The aberrant expression or mutation of GNG4 can disrupt normal signaling pathways contributing to disease pathology. In neuropsychiatric disorders GNG4 interacts with dopamine receptor pathways affecting dopaminergic signaling; this connection suggests a possible link to conditions like schizophrenia. In cancer altered GNG4 expression has been observed in some tumor types indicating its potential involvement in tumorigenesis through signaling pathways linked to other proteins such as Ras.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854153076905,"sku":"ab238868","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab238868","provider":"Iright","version":"1.0","type":"link"}