{"product_id":"abcam-ab238911","title":"Abcam, ab238911, Anti-COPT2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal COPT2 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC31A2 aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SLC31A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O15432\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCOPT2 also known as COPTI or Copper Transporter 2 functions mechanically as a transporter protein responsible for moving copper ions across cell membranes. It facilitates the import of essential copper ions into the cells integral for various cellular processes. The mass of COPT2 is approximately 27 kilodaltons. It is mainly expressed in the liver kidneys and brain where cells demand efficient copper ion regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCOPT2 plays an important role in maintaining copper homeostasis within the body allowing proper cellular functions that require copper-dependent enzymes. COPT2 is not part of a protein complex but its significance lies in its singular ability to enhance cellular uptake of copper ions. Copper-dependent enzymes such as cytochrome c oxidase and superoxide dismutase rely on COPT2's function to maintain optimal activity within the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nCOPT2 is directly involved in the copper regulation pathway ensuring that cells receive sufficient copper ions for enzymatic activities. This pathway also interacts with metallothioneins which are proteins responsible for metal detoxification and storage. COPT2's function complements other copper transport proteins like ATP7A and ATP7B which help in exporting and distributing copper within the body.\u003cbr\u003e\nDisturbances in COPT2 function contribute to conditions such as Wilson's disease and Menkes disease. Wilson's disease results from copper accumulation due to impaired copper transport while Menkes disease involves defective copper absorption. COPT2 works alongside proteins like ATP7B in Wilson's disease and ATP7A in Menkes disease highlighting its important involvement in managing copper ion levels and maintaining cellular health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854224969897,"sku":"ab238911","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab238911","provider":"Iright","version":"1.0","type":"link"}