{"product_id":"abcam-ab238975","title":"Abcam, ab238975, Anti-Fyn (phospho Y530) + Yes1 (phospho Y537) antibody [EPR13512] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal FYN phospho Y530 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13512,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab238975 is the carrier-free version of\u003cbr\u003e\nab188319\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFyn and Yes1 are Src family kinases key players in signal transduction processes within cells. They share similarities in function and mechanism often grouped together due to their roles in cellular phosphorylation events. Fyn and Yes1 have a molecular mass of approximately 59 kDa and are ubiquitously expressed in many tissues including brain thymus and T lymphocytes. Fyn known also as p59fyn contributes significantly to the regulation of immune response and neuronal signaling by phosphorylation of different substrates.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFyn and Yes1 influence various cellular processes such as cell growth differentiation and survival. They form part of the larger signaling complexes that regulate cytoskeleton organization helping in maintaining cell structure and motility. When activated they communicate changes in the cellular environment by phosphorylating tyrosine residues on target proteins affecting downstream signaling pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nBoth Fyn and Yes1 play major roles in the mitogen-activated protein kinase (MAPK) pathway and the phosphoinositide 3-kinase (PI3K) pathway. These pathways are fundamental for transmitting extracellular signals to the cell nucleus triggering responses like cell proliferation or survival. Through these pathways Fyn and Yes1 interact with various proteins including phospholipase C-gamma (PLCγ) and SH2 domain-containing proteins. Their activation leads to further signaling cascades that impact cellular outcomes.\u003cbr\u003e\nAberrant Fyn and Yes1 activity have been linked to cancer and neurodegenerative disorders. Overexpression or mutation of these kinases can lead to uncontrolled cell proliferation contributing to breast cancer. In the context of neurodegenerative diseases Fyn interacts with the amyloid precursor protein implicated in Alzheimer's disease. Understanding these connections provides potential therapeutic targets for intervention in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851922165929,"sku":"ab238975","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab238975","provider":"Iright","version":"1.0","type":"link"}