{"product_id":"abcam-ab238976","title":"Abcam, ab238976, Anti-TXNL1 antibody [EPR16061(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TXNL1 antibody. Carrier free. Suitable for WB, ICC\/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16061(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab238976 is the carrier-free version of\u003cbr\u003e\nab188328\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein TXNL1 also known as thioredoxin-like-1 functions mechanically as a member of the thioredoxin family. It contains an active site with a redox-active disulfide bond which allows it to facilitate electron transfer reactions. TXNL1 has a molecular mass of approximately 32 kDa. This protein is expressed in various tissues with distinctive presence in the heart skeletal muscles and liver.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTXNL1 plays a role in maintaining cellular redox homeostasis and regulates the oxidative stress response. It participates in the thioredoxin complex working alongside other thioredoxin family members to reduce oxidized proteins within cells. By restoring proteins to their functional state TXNL1 helps ensure proper cellular function and protects against damage from reactive oxygen species.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of TXNL1 extends to key cellular signaling pathways including the Nrf2-mediated antioxidant pathway and the MAPK pathway. In the Nrf2 pathway TXNL1 impacts the regulation of antioxidant response elements supporting cell survival under stress conditions. Within the MAPK pathway it interacts with signaling proteins such as JNK modulating stress responses and apoptosis.\u003cbr\u003e\nTXNL1 shows a connection to conditions like cardiovascular disease and neurodegenerative disorders. Its role in oxidative stress makes it relevant in cardiovascular disease where imbalance in redox homeostasis contributes to disease progression. In neurodegenerative disorders interactions of TXNL1 with proteins such as Nrf2 play part in modulating neuronal survival and apoptosis highlighting its potential influence on disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851636396201,"sku":"ab238976","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab238976","provider":"Iright","version":"1.0","type":"link"}