{"product_id":"abcam-ab238985","title":"Abcam, ab238985, Anti-RNA Helicase A antibody [EPR13521] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RNA Helicase A antibody. Carrier free. Suitable for WB, ICC\/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13521,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab238985 is the carrier-free version of\u003cbr\u003e\nab183731\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRNA Helicase A also known as DHX9 is a protein essential for various cellular processes. This helicase protein belongs to the DEXH-box family and facilitates the unwinding of RNA structures which is critical for RNA metabolism. The molecular weight of RNA Helicase A is approximately 141 kDa. It is expressed in a variety of human tissues including the nucleus cytoplasm and sometimes nucleoli. The protein’s helicase activity is central to its mechanical role in cellular functioning.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRNA Helicase A is involved in numerous processes such as transcription RNA processing and the assembly of ribonucleoprotein complexes. The protein plays an important role in facilitating RNA polymerase II transcription and also has functions in RNA splicing through its association with spliceosomal components. RNA Helicase A does not function in isolation; instead it forms part of multi-protein complexes that are necessary for its diverse cellular roles. It interacts with various proteins to achieve its functions impacting both RNA and DNA substrates.\u003cbr\u003e\nPathways\u003cbr\u003e\nRNA Helicase A influences the regulation of gene expression and is a significant player in the innate immune response. It participates in the Toll-like receptor (TLR) signaling pathway where it helps detect viral RNA and triggers immune responses. It also interacts with proteins like TLR3 and TRIF which are involved in the signaling cascade essential for producing type I interferons and pro-inflammatory cytokines.\u003cbr\u003e\nRNA Helicase A has associations with cancer and viral infections. Abnormal regulation of RNA Helicase A has been linked with tumorigenesis where its altered expression contributes to oncogenic processes. It also plays a part in the host response to viral infections where the protein aids in recognizing viral nucleic acids. RNA Helicase A interacts with viral proteins thereby influencing viral replication and host antiviral responses. These connections highlight the protein’s relevance in both cancer biology and infectious disease pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851628990633,"sku":"ab238985","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab238985","provider":"Iright","version":"1.0","type":"link"}