{"product_id":"abcam-ab240008","title":"Abcam, ab240008, Anti-ZNF217 antibody [EPR6362] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ZNF217 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6362,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab240008 is the carrier-free version of\u003cbr\u003e\nab124927\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZNF217 also known as Zinc Finger Protein 217 functions mechanically as a transcriptional repressor and is part of the Krüppel-like C2H2 zinc finger proteins. It has a molecular mass of approximately 121 kDa. ZNF217 is primarily expressed in tissues such as the brain prostate and breast. It binds to specific DNA sequences and regulates gene expression often altering cellular differentiation and proliferation by repressing or activating target genes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZNF217 plays a significant role in cellular processes such as cell growth and survival. The protein associates with a multiprotein complex that includes CoREST histone deacetylases and lysine-specific demethylases. This association impacts chromatin remodeling and transcriptional control. ZNF217's influence on gene expression affects important cellular functions including differentiation and apoptosis by modifying chromatin structure and subsequently regulating gene transcription levels.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis transcriptional regulator influences two critical signaling pathways the TGF-beta and PI3K\/AKT pathways both of which are essential for cellular growth and survival. ZNF217 interacts with proteins like SMAD2 which is a part of the TGF-beta pathway affecting cellular proliferation and differentiation processes. Through these connections ZNF217 contributes to the modulation of signaling cascades that control various aspects of cell behavior often with direct impacts on cellular homeostasis and pathology.\u003cbr\u003e\nAltered expression of ZNF217 associates with several cancers including breast cancer and ovarian cancer. Overexpression of ZNF217 correlates with the progression and poor prognosis of these cancers. This zinc finger protein interacts with MYC a well-known regulator involved in many cancers promoting cellular proliferation and survival in oncogenic contexts. These interactions illustrate ZNF217's role in tumorigenesis and highlight its potential as a target for therapeutic interventions in cancer treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850682749097,"sku":"ab240008","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab240008","provider":"Iright","version":"1.0","type":"link"}