{"product_id":"abcam-ab240068","title":"Abcam, ab240068, Anti-CARD9 antibody [EPR6489] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CARD9 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6489,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab240068 is the carrier-free version of\u003cbr\u003e\nab133560\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCARD9 also known as Caspase Recruitment Domain Family Member 9 is a signaling protein that plays a critical role in immune cell function. It has a molecular mass of approximately 59 kDa. CARD9 is primarily expressed in myeloid cells including dendritic cells monocytes and macrophages. Its mechanical function involves acting as an adaptor protein in immune signaling pathways allowing it to mediate the interaction between upstream pattern recognition receptors and downstream kinases.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCARD9 is instrumental in the activation of the immune system’s response to pathogens such as fungi and bacteria. It functions as part of the CARD-Bcl10-MALT1 signaling complex which triggers the activation of NF-kB a transcription factor essential for inflammatory responses. Through its role in this complex CARD9 ensures the regulation of cytokine production which is fundamental for effective immune responses. CARD9's activity supports the defense against pathogenic infections by facilitating communication in immune signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nCARD9 is involved in critical immune response pathways including the C-type lectin receptor (CLR) pathway. This pathway is essential in recognizing fungal pathogens and initiating immune responses. CARD9 interacts with proteins like Syk and Bcl10 in the CLR pathway to propagate immune signaling. CARD9's role in these pathways highlights its significance in regulating immune activities and maintaining homeostasis through signaling cascades.\u003cbr\u003e\nCARD9 deficiency can result in impaired immune responses leading to increased susceptibility to fungal infections such as candidiasis. The protein plays an important role in maintaining appropriate immune functions to prevent such conditions. Furthermore dysfunction in CARD9 signaling has been associated with inflammatory bowel diseases. In this context CARD9 interacts with other immune proteins like NOD2 to modulate intestinal inflammation. Understanding CARD9’s role helps in elucidating its potential as a therapeutic target for managing these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851279290537,"sku":"ab240068","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab240068","provider":"Iright","version":"1.0","type":"link"}