{"product_id":"abcam-ab240965","title":"Abcam, ab240965, Anti-HNF6 antibody [EPR14976] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HNF6 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14976,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab240965 is the carrier-free version of\u003cbr\u003e\nab186743\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHepatocyte nuclear factor 6 (HNF6) also known as Onecut1 is a transcription factor that functions to regulate gene expression. It has a molecular mass of approximately 55 kDa. HNF6 is expressed in the liver pancreas and several other tissues influencing the development and function of these organs. It plays a significant role in regulating genes involved in various cellular processes by binding to DNA sequences and controlling transcription.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis transcription factor controls the development and maturation of pancreatic islets and hepatocytes. It does not usually function as part of a larger protein complex but it directly influences genes that are vital for these processes. HNF6 ensures proper liver cell differentiation and has an important role in managing glucose metabolism and bile acid homeostasis in tissues where it is expressed.\u003cbr\u003e\nPathways\u003cbr\u003e\nHepatocyte nuclear factor 6 is integral to the glucose metabolism and bile acid biosynthesis pathways. It interacts with other transcription factors such as HNF4α and FOXA2 forming a regulatory network. HNF6 affects gene expression involved in maintaining metabolic balance and liver detoxification processes illustrating its critical influence on metabolic function within these pathways.\u003cbr\u003e\nHNF6 links to diabetes and liver diseases. Its modulation of pancreatic development and function implicates it in both type 1 and type 2 diabetes often involving its interaction with other transcription factors like PDX1 and MafA. Similarly changes in HNF6 expression affect liver diseases such as cholestasis where it impacts bile acid regulation and liver cell function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851014951081,"sku":"ab240965","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab240965","provider":"Iright","version":"1.0","type":"link"}