{"product_id":"abcam-ab241023","title":"Abcam, ab241023, Albumin Depletion Kit","description":"\u003cp\u003eSize: 25Test\u003cbr\u003e\nAlbumin Depletion Kit ab241023 provides easy and user-friendly spin columns for the depletion\/removal of abundant albumin protein from samples for downstream applications. - Uses Cibacron blue immobilized on beads for albumin binding - Each spin column can bind ~2-3 mg albumin - Produce ready-to- use albumin-depleted samples in 60 minutes\u003cbr\u003e\nKey facts\u003cbr\u003e\nSample types:Purified protein\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAlbumin Depletion Kit (ab241023) provides easy and user-friendly spin columns for the depletion\/removal of abundant albumin protein from samples thus enhancing the sample analysis. The kit is based on the interaction of Cibacron Blue 3G-A (immobilized on beads) with albumin. Each spin column can bind ~2-3 mg of albumin and processes samples in less than one hour. After albumin depletion, samples can be used for subsequent ELISA, immunoassays and other downstream analyses such as gel electrophoresis and functional assays. These columns can also be used for purification and enrichment of a variety of Cibacron Blue dye-binding proteins.\u003cbr\u003e\nPlease note, this kit has only been tested on human samples.\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called K6573 EZAlbumin™ Depletion Kit (Spin Column). K6573-25 is the same size as the 25 test size of ab241023.\u003cbr\u003e\nThe Safety Datasheet for this product has been updated for certain countries. Please check the current version in the Support and downloads section.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAlbumin also known as ALB is a major plasma protein with a molecular mass of approximately 66.5 kDa. It predominantly gets synthesized in the liver and found abundantly in blood plasma. Albumin serves multiple functions including maintaining osmotic pressure and acting as a carrier protein for various endogenous substances like hormones fatty acids and bilirubin.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAlbumin plays a critical role in transporting small molecules like metabolites and drugs through the circulatory system. It is not a part of any complex but functions independently to bind transport and release various ligands. Albumin's affinity for hydrophobic molecules makes it essential for they to be solubilized in blood for proper metabolism and excretion.\u003cbr\u003e\nPathways\u003cbr\u003e\nMore than five binding sites on albumin facilitate its role in the fatty acid metabolism and renin-angiotensin system pathways. In fatty acid metabolism albumin interacts with transport proteins carrying fatty acids to tissues for energy production. Additionally during the renin-angiotensin system albumin modulates blood pressure through its interaction with angiotensin II which can influence vasoconstriction.\u003cbr\u003e\nResearchers link albumin with nephrotic syndrome and liver cirrhosis. In nephrotic syndrome low levels of albumin (albumin low) can cause edema due to imbalanced osmotic pressure. In liver cirrhosis a reduction in albumin synthesis signifies liver damage. Albumin's interaction with proteins like angiotensin II correlates with complications such as hypertension further establishing the protein's role in health and disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847601934505,"sku":"ab241023","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab241023","provider":"Iright","version":"1.0","type":"link"}