{"product_id":"abcam-ab241205","title":"Abcam, ab241205, Anti-SLC39A6\/ZIP-6 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal SLC39A6\/ZIP-6 antibody. Suitable for WB, IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC39A6 aa 100-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SLC39A6 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.Q13433\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLC39A6 also known as ZIP-6 functions as a zinc transporter involved in importing zinc into cells from the extracellular environment. This protein is part of the ZIP family and has a mass of approximately 93 kDa. ZIP-6 is frequently expressed in tissues such as liver kidney and various epithelial cells. ZIP transporters like ZIP-6 play an important role in zinc homeostasis by facilitating cellular uptake of this essential trace element which impacts many cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZIP-6 actively regulates intracellular zinc levels essential for many cellular functions like growth and development. It exists independently and does not directly form a part of a larger complex. ZIP-6 enhances zinc-dependent signaling pathways and is necessary for different cellular tasks like gene expression and enzyme activity. By controlling zinc entry into cells ZIP-6 supports several zinc-driven biological processes impacting cellular metabolism and survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers link ZIP-6 to the JAK-STAT signaling and MAPK pathways. In these pathways zinc acts as a necessary cofactor for numerous enzymes and transcription factors. ZIP-6's zinc transport activity connects with proteins such as STAT3 in the JAK-STAT pathway influencing cell proliferation and differentiation. ZIP-6's regulation of zinc concentrations affects the MAPK pathway which includes proteins like ERK1\/2 highlighting its involvement in signal transduction and cellular response to stimuli.\u003cbr\u003e\nZIP-6 plays an essential role in cancer progression and immune system dysfunctions. Overexpression of ZIP-6 associates with breast cancer where it can promote proliferation and metastasis by affecting zinc-dependent pathways. ZIP-6 activity relates also to immune-related disorders influencing the inflammatory response through interactions with NF-kappaB. Changes in the activity or expression of ZIP-6 alter zinc homeostasis adding complexity to its disease-related impact.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853935104169,"sku":"ab241205","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab241205","provider":"Iright","version":"1.0","type":"link"}