{"product_id":"abcam-ab241975","title":"Abcam, ab241975, Anti-DDHD1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal DDHD1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DDHD1 aa 50-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human DDHD1 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q8NEL9\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241975 was affinity purified using an epitope specific to DDHD1 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe DDHD1 protein also known as DDH1 or PA-PLA1 is a phospholipase involved in lipid metabolism. With a molecular mass of approximately 88 kDa this protein localizes primarily in the cytosol but can also associate with the Golgi apparatus. DDHD1 is expressed in various tissues with significant levels in the brain and testis. This expression pattern suggests its potential role in central nervous system functions and reproductive processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDDHD1 enzyme is responsible for the hydrolysis of phosphatidic acid contributing to lysophospholipid production. It is part of the intracellular membrane trafficking system operating independently rather than as part of a complex. By modulating the lipid composition of membranes DDHD1 helps regulate membrane curvature and dynamics which affects cellular processes such as vesicular transport and signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nDDHD1 plays a significant role in the phospholipid signaling pathway by acting on phosphatidic acids. Its activity influences the levels of signaling molecules like lysophosphatidic acid which impact cellular events like proliferation and migration. Additionally DDHD1 is involved in the arachidonic acid pathway connecting it with enzymes such as PLA2 which also mediate the release of fatty acids from phospholipids essential for inflammatory responses.\u003cbr\u003e\nDDHD1 mutations have been associated with hereditary spastic paraplegia a neurodegenerative condition characterized by progressive weakness and spasticity of the lower limbs. This relationship indicates its contribution to maintaining neuronal integrity. Furthermore DDHD1 function has links to mitochondrial lipid homeostasis associating it with DDHD2 in the context of complex lipid synthesis disorders especially those affecting the nervous system.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853985992873,"sku":"ab241975","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab241975","provider":"Iright","version":"1.0","type":"link"}