{"product_id":"abcam-ab242093","title":"Abcam, ab242093, Anti-MTFR1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MTFR1 antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MTFR1 aa 250 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MTFR1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q15390\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab242093 has not performed satisfactorily when used for WB of MTFR1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of MTFR1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to MTFR1 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMTFR1 also known as mitochondrial fission regulator 1 is a protein involved in mitochondrial dynamics. It has a molecular mass of approximately 32 kDa. This protein is predominantly expressed in tissues with high metabolic demand such as muscle and liver. MTFR1 plays a role in mitochondrial fission impacting how mitochondria divide and distribute within cells. The protein's regulation of mitochondrial shape and distribution affects energy supply and cellular homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe regulation of mitochondrial fission by MTFR1 is important for energy production and cell signaling. It is often found as part of a larger protein complex that works together to execute mitochondrial fission. This function ensures that cells have the necessary energy supply and can properly react to metabolic changes. The balance between mitochondrial fission and fusion maintains cellular functions and supports cellular adaptation to metabolic stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nMTFR1 integrates into pathways involved in energy homeostasis and mitochondrial quality control. It plays a role in the mitochondrial fission pathway interacting with proteins like DRP1 (Dynamin-related protein 1) which is important for driving the division of mitochondria. MTFR1 also influences pathways affecting metabolic control linking mitochondrial dynamics to broader cellular functions and energy balance.\u003cbr\u003e\nMTFR1 dysregulation has associations with neurodegenerative diseases like Parkinson's disease and metabolic disorders such as diabetes. MTFR1’s interaction with DRP1 and other fission proteins influences mitochondrial function and may lead to mitochondrial dysfunction contributing to the pathogenesis of these conditions. Understanding how MTFR1 and its network influence these diseases may offer insights into potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853986123945,"sku":"ab242093","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab242093","provider":"Iright","version":"1.0","type":"link"}