{"product_id":"abcam-ab242119","title":"Abcam, ab242119, Anti-EVPL antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal EVPL antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EVPL aa 1950 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human EVPL aa 1950 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92817\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab242119 has not performed satisfactorily when used for WB of EVPL in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of EVPL.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to EVPL immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEVPL also known as Envoplakin is a protein with a molecular weight of approximately 201 kDa. It plays a mechanical role in forming the cornified envelope in keratinocytes providing structural integrity and barrier function to the skin. EVPL constitutes one of the proteins in the plakin family. It predominantly expresses in epithelial tissues especially in the stratified squamous epithelia including skin and mucosal surfaces.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe EVPL protein contributes to cell-cell adhesion and cytoskeletal organization. It functions as a linker protein that anchors intermediate filaments to desmosomes which are cell structures that maintain tissue integrity. As a component of the desmosome complex EVPL interacts with other plakins and proteins such as periplakin and desmoplakin which together ensure the mechanical stability of cells in tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nEnvoplakin plays an important role in the cornified envelope formation pathway and the cell adhesion pathways. It engages with proteins like involucrin and loricrin which are essential for cross-linking and stabilizing the extracellular matrix within the skin layers. This activity helps in maintaining skin elasticity and resilience against mechanical stress.\u003cbr\u003e\nEVPL has associations with skin disorders such as palmoplantar keratoderma and pemphigus. In these conditions structural defects in desmosomes or associated components lead to compromised cell-cell adhesion. Additionally the protein can link to desmoplakin which is involved in similar diseases demonstrating its significant impact on maintaining skin health and integrity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853941952681,"sku":"ab242119","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab242119","provider":"Iright","version":"1.0","type":"link"}