{"product_id":"abcam-ab243901","title":"Abcam, ab243901, Anti-c-Maf antibody [BLR045F] - BSA free","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal c-Maf antibody. Suitable for IHC-P, ICC, IP, WB and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MAF aa 100-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:BLR045F,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MAF aa 100-200. The exact immunogen used to generate this antibody is proprietary information.O75444\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is sold under License from Bethyl Laboratories, Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification notes-Recombinant antibody was purified from cell culture supernatant., Storage buffer-pH: 7.8 - 8.6Preservative: 0.09% Sodium azideConstituents: 99% Borate buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe c-Maf protein also known as Maf or MAF is a member of the large MAF family of basic leucine zipper (bZIP) transcription factors. This protein plays a significant role in the regulation of gene expression. It has a molecular weight of approximately 38 kDa. c-Maf is commonly expressed in various tissues such as the lens of the eye the kidneys and specific immune cells including T cells and macrophages. It is widely studied due to its involvement in transcriptional activation of certain target genes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC-Maf protein influences cellular differentiation and function particularly in immune cells. It forms part of a transcriptional complex that regulates genes critical for the production of interleukins and other cytokines. In the immune system c-Maf is essential for the differentiation of T-helper 2 cells and influences the production of cytokines such as IL-4. Additionally it is involved in the maturation of lens fibers in the eye and modulation of renal functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nC-Maf plays an important role in the immune and visual system. It is part of the signaling pathways that regulate Th2 cytokine genes including IL-4 within the adaptive immune response. This process involves interaction with other transcription factors such as STAT6 and GATA3. Moreover the lens development pathway also includes c-Maf where it works with proteins like CRYAA to maintain lens transparency and function.\u003cbr\u003e\nC-Maf has been linked to multiple myeloma and juvenile idiopathic arthritis. c-Maf is often upregulated in multiple myeloma a cancer of plasma cells where it influences proliferation and survival of the malignant cells through its target genes like cyclin D2. Furthermore in juvenile idiopathic arthritis c-Maf contributes to the dysregulation of inflammatory cytokines indirectly involving proteins like IL-10 and IL-21. Understanding c-Maf’s function aids in exploring therapeutic targets for these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850329804969,"sku":"ab243901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab243901","provider":"Iright","version":"1.0","type":"link"}