{"product_id":"abcam-ab246808","title":"Abcam, ab246808, Anti-Tau Alzheimer’s Disease antibody [GT-38] - Conformation-Specific","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-Tau Alzheimer’s Disease antibody [GT-38] - Conformation-Specific (ab246808) is a mouse monoclonal antibody detecting Tau Alzheimer’s Disease in  IHC-P, IHC-Fr, ELISA . Suitable for  Human .\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:GT-38,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-Fr, IHC-P, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Tau Alzheimer’s Disease antibody [GT-38] - Conformation-Specific (ab246808) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), ELISA in Human samples.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [GT-38] also available for your convenience: ab246808, Carrier free -\u003cbr\u003e\nab254274\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab317594\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab317763\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab317764\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab320065\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTau protein also known as MAPT (Microtubule-Associated Protein Tau) plays a mechanical role in stabilizing microtubules in neuronal axons. The human tau protein has several isoforms generally weighing between 45 to 65 kDa. Tau is predominantly expressed in neurons of the central nervous system but can also be found in some non-neuronal cells. In neurons tau binds to tubulin and facilitates the polymerization and stability of microtubules which are essential for maintaining cellular structure and transport functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTau protein impacts the dynamics of the neuronal cytoskeleton. Tau is part of the intracellular transport system where it facilitates the movement of organelles and proteins along axons. This function is essential for neuron communication and resilience. Tau interacts with and regulates microtubule-associated complexes ensuring efficient intracellular transport. Its role in cytoskeletal integrity strongly influences cell signaling pathways critical for synaptic plasticity and neuronal survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nTau protein plays a significant part in cellular transport and signal transduction pathways. One key pathway is the MAPK signaling pathway where tau's phosphorylation state influences neuronal response to external stimuli. Additionally tau is involved in the PI3K\/AKT pathway affecting cell growth and survival. Within these pathways tau's phosphorylation is regulated by kinases including GSK-3Β and CDK5 while phosphatases like PP2A dephosphorylate tau to maintain its functional state.\u003cbr\u003e\nDysfunctional tau is strongly linked to neurodegenerative diseases particularly Alzheimer's disease (AD) and frontotemporal dementia (FTD). In AD hyperphosphorylated tau forms neurofibrillary tangles which disrupt neuronal function and promote cell death. This process often involves other proteins such as beta-amyloid which exacerbate tau's pathological aggregation. Understanding tauopathy mechanisms has guided the research and development of anti-tau antibodies like anti-GT3 and anti-conformation antibodies as therapeutic strategies against tau-related pathologies in neurodegenerative disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847917621417,"sku":"ab246808","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab246808","provider":"Iright","version":"1.0","type":"link"}