{"product_id":"abcam-ab247021","title":"Abcam, ab247021, Anti-REXO5 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal REXO5 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human REXO5 aa 300-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human REXO5 aa 300-500. The exact immunogen used to generate this antibody is proprietary information.Q96IC2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nREXO5 also known as REXO5 exonuclease has a significant role in RNA metabolism. It is an exonuclease enzyme with a mass of approximately 35 kDa recognized for its ability to degrade RNA molecules by cleaving phosphodiester bonds. REXO5 is expressed in various tissues with notable expression levels in the liver and kidney highlighting its possible importance in these organs. The protein exhibits nuclear localization suggesting its functions are closely linked to nuclear processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nREXO5 participates in RNA processing and degradation. It does not form part of a larger multiprotein complex but instead acts individually in exerting its enzymatic function. The protein helps maintain RNA homeostasis by ensuring the proper turnover and degradation of RNA molecules. This function is essential for the regulation of gene expression as it prevents the accumulation of defective or unnecessary RNA which could interfere with cellular activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe REXO5 protein engages in RNA surveillance and decay pathways. It plays a role in the nonsense-mediated decay pathway that targets aberrant mRNA for degradation which is important for quality control in gene expression. REXO5 works alongside proteins such as UPF1 an important player in recognizing and targeting faulty mRNA for breakdown. These interactions ensure the fidelity of genetic information and contribute to the stability of cellular function.\u003cbr\u003e\nChanges in the function or expression of REXO5 have been linked to cancer and neurodegeneration. Abnormal activity can lead to the accumulation of defective RNA possibly contributing to the onset and progression of these conditions. In cancer poor RNA decay might interact with oncogenic pathways potentially involving proteins such as c-Myc known to affect RNA processing and stability. Understanding REXO5's role in these diseases can offer insight into new therapeutic targets and strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854192529577,"sku":"ab247021","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab247021","provider":"Iright","version":"1.0","type":"link"}