{"product_id":"abcam-ab247074","title":"Abcam, ab247074, Anti-PTMA antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PTMA antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTMA aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PTMA aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P06454\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProthymosin alpha (PTMA) also known as prothymosin is a small nuclear protein characterized by a polypeptide chain with a molecular mass of approximately 12 kDa. PTMA is broadly expressed across various tissues with abundant levels in the thymus and spleen. Its sequence is rich in acidic amino acids a feature that influences its interaction with other biomolecules. Prothymosin alpha undergoes post-translational modifications further affecting its functions within the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProthymosin alpha plays a role in chromatin remodeling and regulation of gene expression. It acts as part of the chromatin-modifying complex interacting with other proteins to influence transcription processes. PTMA contributes to cell proliferation and apoptosis aiding cellular defense mechanisms. Its presence in the nucleus is significant for the cell cycle where it regulates the transition between phases.\u003cbr\u003e\nPathways\u003cbr\u003e\nPTMA participates in the apoptotic pathways and the regulation of gene transcription. It works closely with proteins such as histone acetyltransferase complexes which are important for modifying chromatin structure and facilitating transcription. Prothymosin alpha interacts with apoptosis regulatory proteins impacting how cells respond to apoptotic signals and controlling cellular growth and death.\u003cbr\u003e\nPTMA has connections with cancer and autoimmune diseases. Its involvement in cell proliferation links it to oncogenesis where overexpression of PTMA has been observed. The protein also interfaces with immune regulatory proteins influencing autoimmune conditions. PTMA’s dysregulation can induce abnormal cell cycle progression contributing to disease development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854139674793,"sku":"ab247074","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab247074","provider":"Iright","version":"1.0","type":"link"}