{"product_id":"abcam-ab247644","title":"Abcam, ab247644, Anti-AVEN antibody [EP4721] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal AVEN antibody. Carrier free. Suitable for WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP4721,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab247644 is the carrier-free version of\u003cbr\u003e\nab108354\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAVEN also known as Apoptosis and Caspase Activation Inhibitor is a protein that acts to inhibit apoptotic cell death. It weighs approximately 36 kDa. Expression of AVEN occurs in several tissues including the brain heart and skeletal muscle. Inhibiting apoptosis helps cells survive under stress conditions making AVEN a target of interest for studying cell survival mechanisms.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein serves to safeguard cells from apoptosis. It achieves this by preventing the activation of caspases which are important in the execution of programmed cell death. As part of an apoptosome complex AVEN interacts with apoptotic protease activating factor-1 (Apaf-1) to maintain cell viability under stress conditions and prevent early apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nAVEN integrates into both intrinsic and extrinsic apoptotic pathways. In the intrinsic pathway it associates with proteins like Bcl-2 to maintain mitochondrial integrity and prevent release of cytochrome c. Within the extrinsic pathway AVEN influences Fas receptor-mediated caspase activation which further showcases its role in regulating cell death and survival decisions in response to external signals.\u003cbr\u003e\nAVEN expression exhibits implications in cancer and neurodegenerative disorders. Dysregulation of AVEN expression links to various cancers as its apoptosis-inhibiting function promotes tumor cell survival. Additionally AVEN interacts with proteins like Bcl-2 in neurodegenerative disorders such as Alzheimer’s where disrupted apoptosis is a critical factor. Understanding AVEN's function helps in advancing targeted therapies and diagnostics in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851271655593,"sku":"ab247644","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab247644","provider":"Iright","version":"1.0","type":"link"}