{"product_id":"abcam-ab247670","title":"Abcam, ab247670, Anti-P2Y13 antibody [EPR3698] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal P2Y13 antibody. Carrier free. Suitable for WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3698,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab247670 is the carrier-free version of\u003cbr\u003e\nab108444\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nP2Y13 also known as P2RY13 is a G-protein coupled receptor part of the P2Y receptor family. It has a mass of approximately 42 kDa. Functionally P2Y13 recognizes extracellular nucleotides like ADP and initiates signaling cascades thereafter. This receptor is expressed in various tissues including the brain liver and immune cells. In the nervous system it plays a role in neurotransmission and might influence neuronal functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nP2Y13 participates in purinergic signaling. This pathway influences cellular responses and plays a role in multiple physiological processes. P2Y13 is not known to form part of a larger receptor complex but interacts with G-proteins to transmit signals within the cell. Its activity helps regulate lipid metabolism and influences energy homeostasis in the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nP2Y13 is involved in the ADP-mediated signaling pathway a critical component in the regulation of cholesterol and lipid metabolism. It interacts with proteins like G-protein subunits to activate downstream signaling pathways. In the broader context of these pathways P2Y13 supports cellular processes such as energy balance and detoxification of substances.\u003cbr\u003e\nP2Y13 has been connected with cholesterol imbalance and related metabolic disorders. Its role in lipid homeostasis indicates it might be relevant in atherosclerosis a condition characterized by lipid accumulation in the arteries. P2Y13 also associates with neurological disorders due to its presence and role in neural tissues. It is connected to other purinergic receptors like P2Y12 in these disease contexts which collectively contribute to disease progression through dysregulated purinergic signaling.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851591307433,"sku":"ab247670","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab247670","provider":"Iright","version":"1.0","type":"link"}