{"product_id":"abcam-ab247757","title":"Abcam, ab247757, Anti-HLA B7 antibody [EPR2623(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HLA B antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR2623(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Based on homology (92-100%), this product is predicted to recognize HLA-A\/C\/E\/F\/G; however, this has not been experimentally validated.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab247757 is the carrier-free version of\u003cbr\u003e\nab109089\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHLA-B7 also known as HL-A B7 is a part of the human leukocyte antigen (HLA) system and belongs to the HLA class I heavy chain paralogs. This protein has a molecular mass of approximately 45 kDa. HLA-B7 is expressed on the surface of nearly all nucleated cells in the body. Its main role is to present peptide antigens to the immune system specifically to cytotoxic T cells which play an important part in immune response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHLA-B7 is involved in antigen presentation as a part of the major histocompatibility complex (MHC) class I molecule. HLA-B7 like other HLA class I molecules presents endogenous peptides to CD8+ T cells. The HLA B27 pair although different from HLA-B7 shares functional similarities that influence immune surveillance and activation processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nHLA-B7 participates in the antigen processing and presentation pathway. This pathway allows the presentation of intracellularly derived peptides at the cell surface which are recognized by T cell receptors (TCR) on CD8+ T lymphocytes. HLA-B7 works in concert with proteasomes for peptide generation and with transporter associated with antigen processing (TAP) for delivering peptides to the endoplasmic reticulum.\u003cbr\u003e\nHLA-B7 is linked with certain autoimmune diseases and viral infections. Some studies suggest an association with increased susceptibility to diseases such as sarcoidosis. Moreover individuals who are HLA-B7 positive may differ in their immune response to viral infections like HIV. The interaction between HLA-B7 and proteins like beta-2 microglobulin further affects its role in disease mechanisms and immune function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851422716073,"sku":"ab247757","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab247757","provider":"Iright","version":"1.0","type":"link"}