{"product_id":"abcam-ab247877","title":"Abcam, ab247877, Anti-S100 alpha 2\/S100A2 antibody [EPR5392] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal S100 alpha 2\/S100A2 antibody. Carrier free. Suitable for IHC-P, ICC\/IF, IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR5392,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IHC-P, WB, IP, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab247877 is the carrier-free version of\u003cbr\u003e\nab109494\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nS100 alpha 2 also known as S100A2 or CAN19 is a calcium-binding protein that plays a role in the regulation of cell functions. It's part of the S100 protein family and has a mass of approximately 11 kDa. S100A2 is expressed in a variety of tissues including epidermal cells and lung tissue suggesting its involvement in diverse cellular processes. The presence in these tissues indicates a potential role in both skin biology and respiratory system functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nS100A2 influences cell proliferation differentiation and apoptosis. It acts by modulating the activity of target proteins through a calcium-dependent mechanism. Though S100A2 is not known to form a complex with other proteins for its function it interacts with key cell growth regulators affecting cellular responses to external signals. The precise modulation of these processes implicates S100A2 in the maintenance of normal tissue homeostasis and cell cycle regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nS100A2 participates in signal transduction pathways such as the MAPK\/ERK and p53 pathways. In the MAPK\/ERK pathway S100A2 regulates cell cycle progression and cellular responses to growth factors. Additionally in the p53 pathway S100A2 plays a role in apoptosis and tumor suppression. S100A2’s function links it to interaction with critical proteins such as p53 influencing both stress response and genomic stability.\u003cbr\u003e\nS100A2 relates to cancer progression and pulmonary diseases. Altered expression levels of S100A2 have been observed in lung cancer and some skin cancers where it may act as a tumor suppressor. In pulmonary conditions its expression affects tissue responses under pathological states. The interaction of S100A2 with proteins like p53 in these disorders suggests a pivotal role in mediating stress responses and regulating tumor growth providing potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844237119657,"sku":"ab247877","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab247877","provider":"Iright","version":"1.0","type":"link"}