{"product_id":"abcam-ab247936","title":"Abcam, ab247936, Anti-PKC theta\/PRKCQ antibody [EPR1487(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PKC theta\/PRKCQ antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR1487(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab247936 is the carrier-free version of\u003cbr\u003e\nab110728\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPKC theta also known as PRKCQ is a protein kinase involved in signal transduction. The mass of PKC theta is approximately 85 kDa. It is a member of the protein kinase C (PKC) family which has distinctive roles in cellular processes. PKC theta specifically localizes in T-cells and is an important player in immune system functions. It is expressed predominantly in lymphoid tissues such as the spleen and thymus where T-cell activation and differentiation are significant.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPKC theta participates in T-cell receptor signaling involved in the formation of immune synapses. It is an essential component of the multiprotein complex that includes molecules like LAT SLP-76 and Lck. PKC theta's activation allows the transmission of activation signals leading to the production of cytokines like IL-2. This function is integral to ensuring an effective immune response and the maintenance of immune homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nPKC theta is central in the NF-kB pathway which transmits signals from T-cell receptors to the nucleus promoting gene transcription. It also plays a role in the AP-1 pathway collaborating with proteins such as CARMA1 and BCL10. These pathways underpin the immune response coordinating T-cell activation proliferation and survival linking PKC theta function to several immunological processes.\u003cbr\u003e\nPKC theta has connections with autoimmune conditions such as rheumatoid arthritis and type 1 diabetes. In these disorders its role in T-cell signaling becomes dysregulated. This can lead to the overactive immune response against the body's tissues. Additionally PKC theta may interact with proteins involved in inflammatory signaling like NF-kB exacerbating inflammation and tissue damage. Understanding these relationships is important for developing therapies targeting immune dysregulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851497754793,"sku":"ab247936","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab247936","provider":"Iright","version":"1.0","type":"link"}