{"product_id":"abcam-ab247942","title":"Abcam, ab247942, Anti-TRAPPC2 antibody [EPR3401] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TRAPPC2 antibody. Carrier free. Suitable for WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3401,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab247942 is the carrier-free version of\u003cbr\u003e\nab111848\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRAPPC2 also known as sedlin is a component of the transport protein particle (TRAPP) complex with a molecular mass of approximately 17 kDa. It is a small protein that has a significant role in vesicular trafficking within cells. TRAPPC2 is expressed widely in human tissues with notable levels in the testis skeletal muscle and heart. This protein participates in the regulation of intracellular transport processes by assembling into multi-subunit complexes that facilitate the movement of vesicles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRAPPC2 plays a role in the formation and function of the TRAPP complex which is fundamental for intracellular vesicle trafficking. The TRAPP complex exists in different forms and participates in the tethering of vesicles to target membranes. TRAPPC2’s involvement in this complex influences ER-Golgi transportation impacting how proteins and lipids move inside cells. By working as part of the TRAPP complex TRAPPC2 contributes to the maintenance of cellular homeostasis by controlling the flow and direction of cargo.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRAPPC2 is involved in the secretory pathway which is essential for protein sorting and transport. It interacts with other TRAPP subunits such as TRAPPC3 and TRAPPC9 to ensure effective vesicle fusion and trafficking processes. In addition to the secretory pathway TRAPPC2 is engaged in the autophagy pathway. Through its participation in these pathways TRAPPC2 affects how cells manage and recycle cellular components under varying conditions.\u003cbr\u003e\nMutations in TRAPPC2 are linked to X-linked spondyloepiphyseal dysplasia tarda a skeletal disorder affecting bone growth and development. The deficiency of TRAPPC2 disrupts normal vesicular trafficking ultimately leading to the symptoms observed in this disorder. TRAPPC2’s interactions with proteins such as TRAPPC3 and TRAPPC9 through these pathways underline its significance in maintaining cellular functions that when altered result in specific pathological states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851497459881,"sku":"ab247942","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab247942","provider":"Iright","version":"1.0","type":"link"}