{"product_id":"abcam-ab248002","title":"Abcam, ab248002, Anti-RAE1 antibody [EPR6923] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RAE1 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6923,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248002 is the carrier-free version of\u003cbr\u003e\nab124783\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRAE1 also known as Regulator of Chromosome Condensation 1 is a protein with a molecular mass of approximately 44 kDa. This protein primarily binds to mRNA facilitating its export from the nucleus to the cytoplasm. Expressed abundantly in multiple tissues RAE1 plays an integral role in the cellular machinery that governs mRNA transport. It directly interacts with the nuclear pore complex exhibiting specific binding with the nucleoporins a component essential for mRNA export.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRAE1 functions as a part of the mRNA export machinery ensuring accurate and efficient mRNA transfer to the cytoplasm. It forms a complex with Nup98 an important player in nucleocytoplasmic transport. This interaction highlights its significance in mRNA processing and maintaining RNA stability within cells. By collaborating with other export factors RAE1 supports mRNA maturation processes that are critical for subsequent translation into proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nRAE1 takes an active role in the nucleocytoplasmic transport pathway and influences the gene expression regulation pathway. Both these pathways are vital for converting genetic information into functional proteins. RAE1 also collaborates with proteins such as Nup98 and CRM1 which further illustrates its importance in the complex network of cellular transport systems. These pathways integrate signals that ensure the appropriate expression and localization of mRNA thereby forming an essential link between transcription and translation.\u003cbr\u003e\nAbnormalities in RAE1 function can relate to cancer and neurological disorders. Disruptions in mRNA transport where RAE1 is a critical component have been observed in several cancer types highlighting its relationship with oncogenic processes. Additionally improper interaction between RAE1 and Nup98 may contribute to conditions affecting neural function suggesting potential connections with neurodegenerative diseases. Understanding RAE1's role in these pathologies may provide insights into developing new therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851401318569,"sku":"ab248002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248002","provider":"Iright","version":"1.0","type":"link"}