{"product_id":"abcam-ab248032","title":"Abcam, ab248032, Anti-SARA antibody [EPR5020] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SARA antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR5020,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248032 is the carrier-free version of\u003cbr\u003e\nab124875\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSARA also known as Smad anchor for receptor activation plays an important mechanical role in cellular signaling. It functions by binding to phosphorylated receptor-regulated Smad proteins (R-Smads) and facilitating their movement and accumulation in the nucleus. SARA has a molecular mass of approximately 150 kDa and is prominently expressed in a variety of tissues including the brain liver and kidney indicating a widespread functional role in physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSARA engages in interactions with several signaling molecules in the cell. It acts as a scaffolding protein that forms part of a complex with the Smad proteins assisting in the regulation of transforming growth factor-beta (TGF-β) signaling. By serving as a critical link between membranes and the cytoplasm it ensures the accurate transmission of signals necessary for cellular responses. Its location and function highlight its vital role in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSARA plays an important role in TGF-β and bone morphogenetic protein (BMP) signaling pathways. These pathways are essential for regulating cellular processes such as proliferation differentiation and apoptosis. SARA interacts with Smad2 Smad3 and Smad7 which are key components of these pathways. Through these interactions SARA helps mediate the transduction of signals that guide complex cellular activities and responses linking external signals to gene expression inside the nucleus.\u003cbr\u003e\nResearch has linked SARA to cancer and fibrotic diseases. Its role in TGF-β signaling suggests that alterations in SARA expression or function can contribute to tumor progression and metastatic processes. Additionally in fibrotic diseases where excess tissue scarring occurs the modulation of the pathway by proteins like Smad2 and Smad3 with SARA's involvement can result in aberrant tissue responses. Understanding SARA's involvement in these conditions may offer potential therapeutic insights.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851604676777,"sku":"ab248032","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248032","provider":"Iright","version":"1.0","type":"link"}