{"product_id":"abcam-ab248048","title":"Abcam, ab248048, Anti-GRO alpha + GRO gamma + GRO beta antibody [EPR4902] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CXCL1\/GRO alpha antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR4902,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248048 is the carrier-free version of\u003cbr\u003e\nab124898\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CXCL1 protein also known as GRO alpha GRO gamma and GRO beta functions as a chemokine involved in the recruitment and activation of neutrophils. The different variants share structural similarities though they have distinct biological effects. It weighs approximately 11 kDa. This target expresses in various tissues with high presence in epithelial cells and endothelial cells as well as in cells of the immune system. Its expression can be highly regulated in response to inflammatory stimuli and it can increase during immune responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis target contributes to inflammation by attracting neutrophils to sites of tissue injury and infection aiding in the immune defense. It does not work as part of a larger complex but it can interact directly with G-protein coupled receptors on leukocytes. These interactions result in the activation of signaling pathways that lead to cell migration and proliferation supporting wound healing and tissue repair processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nCXCL1 is an important player in the chemokine signaling pathway where it interacts with the CXCR2 receptor triggering intracellular signaling cascades. It plays an instrumental role in the NF-kB pathway which regulates the expression of various downstream inflammatory mediators. This chemokine aligns functionally with other CXC chemokines like IL-8 sharing receptor binding to induce similar downstream effects that perpetuate inflammatory responses.\u003cbr\u003e\nCXCL1 implicates in conditions such as chronic inflammation and cancer. Its overexpression can contribute to pathologies like rheumatoid arthritis where it perpetuates joint inflammation and helps sustain the inflammatory environment. Additionally elevated levels of CXCL1 may also exacerbate tumor progression and metastasis in certain cancers by promoting angiogenesis. In these disease contexts CXCL1 interacts with other inflammatory cytokines like TNF-alpha and IL-1 which together magnify the inflammatory or oncogenic signals.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851280732329,"sku":"ab248048","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248048","provider":"Iright","version":"1.0","type":"link"}