{"product_id":"abcam-ab248138","title":"Abcam, ab248138, Anti-HN1 antibody [EPR7364] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HN1 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7364,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248138 is the carrier-free version of\u003cbr\u003e\nab126705\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHN1 also known as Hematological and Neurological Expressed 1 protein is a small protein with a mass of approximately 10 kDa. It expresses in various tissues mainly in hematopoietic and neurological cells. Researchers also identified its expression in some cancerous tissues which suggests its potential role in tumor biology. HN1 exhibits a notable presence in cytoplasmic and nuclear compartments indicating its involvement in multiple cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nExperts believe HN1 participates in cellular development and differentiation. It does not function alone but interacts with other proteins within a larger complex affecting intracellular signaling. This interaction hints at the protein's role in supporting the regulation of cellular growth and hematopoiesis. In addition HN1 influences cellular responses to stress which further supports its relevance in development and disease.\u003cbr\u003e\nPathways\u003cbr\u003e\nHN1 integrates into the Jak-STAT signaling pathway and possibly the Notch signaling pathway. This association with significant signaling pathways implies its role in modulating gene expression linked to cell proliferation and differentiation. HN1 also shows interactions with other proteins in these pathways such as STAT3 suggesting collaborative involvement in regulating cellular responses to external stimuli.\u003cbr\u003e\nScientists have linked HN1 to cancer and neurodegenerative diseases. Its upregulation in various cancer types like breast cancer indicates a potential role in tumor cell proliferation and survival. Additionally in neurodegenerative conditions changes in HN1 expression suggest it might contribute to neuronal dysfunction. Connections to related proteins like BCL2 involved in cell survival highlight HN1’s implications in both cancer progression and neurodegenerative pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851588980905,"sku":"ab248138","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248138","provider":"Iright","version":"1.0","type":"link"}