{"product_id":"abcam-ab248169","title":"Abcam, ab248169, Anti-CD163L1 antibody [EPR6539] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CD163L1 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6539,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248169 is the carrier-free version of\u003cbr\u003e\nab126756\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD163L1 also known as CD163-like 1 or M160 is a protein that acts as a scavenger receptor. This protein mechanically functions by binding to specific ligands and mediates endocytosis. CD163L1 belongs to the scavenger receptor cysteine-rich (SRCR) family which is involved in the clearance of hemoglobin-haptoglobin complexes. It is a type I membrane protein with an approximate mass of 150 kDa. The expression of CD163L1 is mainly detected in monocytes macrophages and certain dendritic cells usually in tissues associated with the immune response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein influences immune system processes related to inflammation. CD163L1 is part of the innate immune system and may be involved in the response to bacterial infections. It participates in the recognition and removal of apoptotic cells and pathogens. Though not a part of a protein complex its function aligns with receptors that mediate anti-inflammatory responses and tissue homeostasis in the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis scavenger receptor associates with the anti-inflammatory pathway particularly in modulating responses to inflammation. It operates within a network involving the clearance and recycling of hemoglobin-heme. CD163L1 is linked with other proteins like CD163 which share similar clearing functions and SRCR domains are evident in their structure confirming their roles in host defense mechanisms.\u003cbr\u003e\nCD163L1 shows relevance in conditions related to inflammation and immune dysfunction. For instance the receptor's activity is noted in the context of atherosclerosis as it can contribute to plaque stability due to its role in clearing hemoglobin-derived oxidants. It also connects to autoimmune diseases through its involvement with the dampening of inflammatory responses. In these conditions CD163L1 coordinates with proteins such as CD163 and other scavenger receptors that modulate immune responses.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851273261225,"sku":"ab248169","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248169","provider":"Iright","version":"1.0","type":"link"}