{"product_id":"abcam-ab248270","title":"Abcam, ab248270, Anti-Alpha 1 microglobulin antibody [EPR5880] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Alpha 1 microglobulin antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR5880,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248270 is the carrier-free version of\u003cbr\u003e\nab129059\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAlpha-1-microglobulin also known as alpha-1-microglycoprotein or A1M is a protein with a mass of approximately 26 kDa. It is mainly expressed in the liver and secreted into the blood plasma. Alpha-1-microglobulin can bind to small peptides and free radicals acting as a scavenger. It exists in a monomeric form and is present in various bodily fluids including urine and amniotic fluid.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein serves as a protective factor against oxidative stress. Alpha-1-microglobulin is part of the lipocalin protein family which has roles in transport of small hydrophobic molecules in extracellular spaces. Its antioxidant properties help protect biological macromolecules from damage induced by oxidative agents. Alpha-1-microglobulin contains heme-binding sites which contribute to its protective biochemical actions.\u003cbr\u003e\nPathways\u003cbr\u003e\nAlpha-1-microglobulin participates in oxidative stress-related and inflammatory pathways. Within the oxidative stress pathway it interacts with heme oxygenase and other heme-binding proteins to mitigate toxic effects of excess free heme. In inflammatory pathways it links with proteins such as albumin and immunoglobulin components which further supports immune response and cellular protection mechanisms.\u003cbr\u003e\nAlpha-1-microglobulin has associations with conditions like preeclampsia and kidney disease. In preeclampsia its levels can indicate oxidative stress and placental dysfunction involving interactions with other proteins such as haptoglobin. In kidney disease altered levels of alpha-1-microglobulin in urine serve as a biomarker for tubular dysfunction connecting it to conditions affecting renal function and health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851581739177,"sku":"ab248270","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248270","provider":"Iright","version":"1.0","type":"link"}