{"product_id":"abcam-ab248301","title":"Abcam, ab248301, Anti-Eph receptor B1\/NET antibody [EPR6457] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Eph receptor B4\/HTK antibody. Carrier free. Suitable for WB and reacts with Mouse, African green monkey, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6457,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human, African green monkey,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Customer data indicates that this antibody reacts with Eph receptor B2 and B4, in addition to B1. Reactivity with receptor B3 is also expected based on 93% identity of the immunogen with the homologous receptor B3 sequence.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248301 is the carrier-free version of\u003cbr\u003e\nab129103\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEph receptor B1 also called NET or B1 receptor is a member of the Eph receptor family. It plays roles in various cellular processes through its mechanical action as a receptor tyrosine kinase. The Eph receptor B1 primarily mediates signaling by binding to ephrin-B ligands. This interaction triggers bidirectional signaling between cells influencing cell positioning shape and movement. Eph receptor B1 which has a molecular weight of approximately 120 kDa expresses highly in tissues like the brain and testes suggesting its importance in these organ systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEph receptor B1 affects cell adhesion migration and tissue patterning by participating in complex networks. These receptors and their ephrin ligands form a complex that enables cross-communication between adjacent cells. Eph receptor B1 modulates processes like synapse formation in the brain thereby impacting neural development and connectivity. As a result it plays a role in maintaining cellular architecture and function in a specific tissue context.\u003cbr\u003e\nPathways\u003cbr\u003e\nEph receptor B1 is an integral part of the Eph\/Ephrin signaling pathway which influences developmental processes and cellular interactions. In this pathway Eph receptor B1 works alongside proteins like ephrin-B to mediate cell-cell communication and signal transduction. This pathway has implications for the formation and remodeling of blood vessels suggesting further links to the angiogenesis pathway. Such pathways are important for translating external signals into cellular responses shaping the biology of tissues and organs.\u003cbr\u003e\nAlterations in Eph receptor B1 function can relate to conditions such as cancer and neurological disorders. In cancers aberrant Eph receptor B1 signaling can promote tumor growth and metastasis with the receptor often associating with proteins like ephrin-B to drive tumorigenic processes. In the context of neurological diseases like Alzheimer's disease disruptions in Eph receptor B1 signaling can affect neural connectivity and function illustrating its role in maintaining brain health. Understanding these connections helps clarify the receptor's impact on disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848569180329,"sku":"ab248301","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248301","provider":"Iright","version":"1.0","type":"link"}