{"product_id":"abcam-ab248307","title":"Abcam, ab248307, Anti-SSRP1 antibody [EPR7894] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SSRP1 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7894,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248307 is the carrier-free version of\u003cbr\u003e\nab129109\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSSRP1 also known as Structure-Specific Recognition Protein 1 has an important role in DNA-related processes. This protein with a molecular weight of about 80 kDa binds DNA to regulate its structure during transcription and replication. SSRP1 localizes in the nucleus and expresses widely across various tissues indicating its broad functional significance. SSRP1 often pairs with SPT16 to form the FACT (Facilitates Chromatin Transcription) complex which aids in nucleosome disassembly and reassembly.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSSRP1 is integral to processes involving chromatin reorganization and transcriptional regulation. It operates as a component of the FACT complex facilitating the modification of chromatin structure enabling access to the underlying DNA for active transcription. By altering nucleosome structure it assists RNA polymerase II in transcribing through chromatin directly influencing gene expression regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nSSRP1 participates actively in DNA transcription and repair mechanisms. It is an essential player in the transcription elongation pathway interacting with RNA polymerase II. Additionally it influences the DNA repair pathways working in concert with proteins such as SPT16 and histones to maintain genomic stability. Its function ensures efficient transcription and protection against DNA damage.\u003cbr\u003e\nSSRP1 connections emerge in the context of cancer and Alzheimer's disease. In cancer SSRP1 expression levels can correlate with tumor progression influencing the behavior of cancer cells through its role in transcriptional regulation. In Alzheimer's alterations in chromatin structure involving SSRP1 may link to disease progression. The activity of SSRP1 interacts with proteins such as p53 in cancer highlighting its role in disease mechanisms and potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851909910697,"sku":"ab248307","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248307","provider":"Iright","version":"1.0","type":"link"}