{"product_id":"abcam-ab248363","title":"Abcam, ab248363, Anti-SIM2 antibody [EPR7878] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SIM2 antibody. Carrier free. Suitable for WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7878,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248363 is the carrier-free version of\u003cbr\u003e\nab131161\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSIM2 also known as Single-minded homolog 2 is a transcription factor belonging to the bHLH-PAS family. It possesses a molecular weight of approximately 88 kDa. SIM2 plays a significant role in regulating gene expression by binding to the DNA hence influencing various biological processes. This protein is predominantly expressed in fetal and adult brain tissues as well as in other tissues including the kidney and lung suggesting its involvement in diverse physiological functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis transcription factor modulates neural development and is implicated in the suppression of tumorigenesis. SIM2 interacts with ARNT (aryl hydrocarbon receptor nuclear translocator) to form a transcriptionally active complex. This complex plays a critical function in maintaining the delicate balance of cellular proliferation and differentiation. SIM2's expression levels change in response to developmental cues indicating its importance in development especially within the nervous system.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protein participates in the hypoxia and circadian rhythms pathways. In the hypoxia pathway SIM2 influences the cellular response to low oxygen levels by interacting with other transcription factors like HIF-1α while in the circadian rhythms pathway it affects the regulation of genes involved in maintaining the body's biological clock. These pathways exhibit how SIM2 integrates external signals demonstrating its function in complex biological networks.\u003cbr\u003e\nThis transcription factor has been associated with Down syndrome and certain types of cancer such as prostate cancer. The downregulation or overexpression of SIM2 can contribute to the aberrant cellular proliferation characteristic of these disorders. Its interaction with other proteins such as ERG in prostate cancer links SIM2 to the progression and pathophysiology of these diseases highlighting its potential as a therapeutic target in understanding and treating these complex conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851272114345,"sku":"ab248363","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248363","provider":"Iright","version":"1.0","type":"link"}