{"product_id":"abcam-ab248393","title":"Abcam, ab248393, Anti-PDCD7 antibody [EPR8231] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PDCD7 antibody. Carrier free. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8231,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248393 is the carrier-free version of\u003cbr\u003e\nab131258\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProgrammed cell death 7 commonly known as PDCD7 is an essential protein in the regulation of cellular apoptosis. PDCD7 weighs about 59 kDa. It is found predominantly in the nucleus though expression can also be seen in the cytoplasm of various cell types. This protein is encoded by the PDCD7 gene and its expression is noticeable in different tissues including lymphoid tissues indicating a role in immune system regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDCD7 contributes to the initiation and progression of apoptosis by interacting with other proteins and forming complexes essential for cellular function. Although PDCD7 itself is not a component of the spliceosome complex it plays a supporting role in RNA splicing indirectly linking it to this significant cellular machinery. This connection influences both cell death and gene expression showcasing its diverse biological role.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral studies highlight PDCD7's involvement in the apoptotic pathway including the intrinsic pathway where it connects with proteins like caspases to execute cell death. It also has a lesser-known role in the spliceosome and its function in RNA processing. In this context PDCD7 interacts with proteins like the FAS receptor which is important in regulating apoptosis following cellular stress or damage.\u003cbr\u003e\nPDCD7 is linked to certain cancers due to its role in apoptosis. Alterations in PDCD7 expression can contribute to malignancies as disrupted apoptosis often leads to unchecked cell proliferation. PDCD7's connection with proteins such as BCL2 which inhibit apoptosis further supports these links to cancer pathogenesis. Additionally abnormal PDCD7 function might influence autoimmune diseases although research continues to uncover the precise mechanisms involved.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851742662825,"sku":"ab248393","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248393","provider":"Iright","version":"1.0","type":"link"}