{"product_id":"abcam-ab248418","title":"Abcam, ab248418, Anti-DN-7 antibody [EPR5266] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DN-7 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR5266,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248418 is the carrier-free version of\u003cbr\u003e\nab133239\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDN-7 also known as Dedicated Nucleotide 7 or DNase-7 is a protein with a molecular mass of approximately 30 kDa. It plays a role in the breakdown of nucleic acids functioning efficiently in cellular environments where DNA turnover is high. DN-7 expression occurs across various tissues with notable levels in the spleen and thymus. This expression pattern reflects its involvement in the degradation of extranuclear DNA helping to maintain cellular homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDN-7 contributes to nucleic acid metabolism where it prevents the accumulation of DNA fragments. Its enzymatic activity facilitates the clearance of excess DNA critical for avoiding autoimmune reactions. DN-7 often partners with other nucleases forming transient complexes that enhance its efficacy particularly during the cell apoptosis process. These interactions highlight its importance in maintaining genomic stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nDN-7 integrates into the apoptosis pathway working alongside proteins such as caspases. Through regulated DNA cleavage DN-7 supports the systematic dismantling of cellular components during apoptosis. Another pathway involving DN-7 is DNA repair where it complements proteins like PARP ensuring any nonspecific DNA damage is adequately resolved to maintain genomic integrity.\u003cbr\u003e\nDN-7 has connections to systemic lupus erythematosus (SLE) and other autoimmune conditions. Insufficient activity of DN-7 can lead to improper DNA clearance a factor contributing to autoimmune responses. Additionally abnormal DN-7 function relates to certain cancer types where its imbalance can influence tumor proliferation. In these contexts DN-7 interacts with proteins like DNase II affecting disease progression and pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850548334761,"sku":"ab248418","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248418","provider":"Iright","version":"1.0","type":"link"}