{"product_id":"abcam-ab248615","title":"Abcam, ab248615, Anti-Dymeclin antibody [EPR8789] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Dymeclin antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8789,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248615 is the carrier-free version of\u003cbr\u003e\nab133685\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDymeclin also known as Dym is a protein involved in cellular processes with a molecular weight of approximately 55kDa. This protein shows expression in various tissues but is especially present in the bone brain and cartilage. As a component of the endosomal system Dymeclin is important for maintaining proper cellular function. It assists in the stability and trafficking of lysosomes by interacting with intracellular compartments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDymeclin participates in the regulation of skeletal development and neuronal functions. It acts within a larger protein complex that plays roles in maintaining cellular homeostasis particularly involving endosomal trafficking. Dymeclin interacts with other proteins to ensure the integrity of organelles and to modulate transport within the cell. This functionality is essential for proper growth and development affecting both bone density and brain function.\u003cbr\u003e\nPathways\u003cbr\u003e\nDymeclin finds involvement in the endocytic and lysosomal pathways. It connects to proteins like Rab7 which is significant for endosomal-lysosomal transport. Through these pathways Dymeclin influences the prevention of premature degradation of cellular components and assists in signal transduction processes. Its interactions within these pathways suggest a role in cellular stress response and adaptation by mediating protein sorting and degradation.\u003cbr\u003e\nMutations or dysfunctions related to Dymeclin lead to bone dysplasia and cognitive impairments. It is strongly associated with Smith-McCort dysplasia and Dyggve-Melchior-Clausen syndrome which involve skeletal abnormalities and intellectual disability. Dymeclin's connection to proteins involved in bone and brain development highlights its influence on the pathogenesis of these disorders emphasizing its role in both structural integrity and cognitive function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851266674857,"sku":"ab248615","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248615","provider":"Iright","version":"1.0","type":"link"}