{"product_id":"abcam-ab248872","title":"Abcam, ab248872, Anti-CCDC98 antibody [EPR6310(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CCDC98 antibody. Carrier free. Suitable for ICC\/IF, IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6310(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248872 is the carrier-free version of\u003cbr\u003e\nab139191\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCCDC98 also known as NABP2 or MERIT40 functions as a protein that assists in the DNA damage response and repair pathways. Its molecular mass is approximately 42 kDa. CCDC98 primarily shows expression in the nucleus of cells. It is essential in repair processes by interacting with other proteins involved in the DNA double-strand break repair mechanism. The protein ensures stability within the BRCA1-A complex playing a role in maintaining genomic integrity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCCDC98 supports cellular processes by stabilizing the BRCA1-A complex which is important for the homologous recombination repair of damaged DNA. This protein forms an important part of the machinery that recognizes and processes DNA damage. It interacts with other core components of the DNA repair system like BRCA1 RAP80 and ABRAXAS ensuring efficient repair and prevention of genomic instability.\u003cbr\u003e\nPathways\u003cbr\u003e\nCCDC98 is integral to the homologous recombination repair and cell cycle checkpoint pathways. Through its association with the BRCA1-A complex CCDC98 influences the recruitment and retention of repair proteins at DNA damage sites a critical event in the DNA damage response pathway. It connects with other proteins such as BRCA1 and RAP80 to regulate repair pathway activities and proper cell cycle progression reinforcing cellular responses to DNA damage.\u003cbr\u003e\nCCDC98 is linked to breast and ovarian cancers. Mutations or dysregulation affecting CCDC98's function can disrupt BRCA1-A complex stability leading to compromised DNA repair ability which is a factor in tumorigenesis. It connects to the BRCA1 protein in these disease contexts where impaired interactions can raise the risk of developing cancer showcasing the significance of this protein in health and disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851837788329,"sku":"ab248872","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248872","provider":"Iright","version":"1.0","type":"link"}