{"product_id":"abcam-ab248887","title":"Abcam, ab248887, Anti-LSS antibody [EPR6703] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal LSS antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6703,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248887 is the carrier-free version of\u003cbr\u003e\nab140124\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe LSS protein also known as lanosterol synthase plays a mechanical role in the biosynthesis of sterols. Its main function involves the cyclization of 23-oxidosqualene to lanosterol. LSS has a molecular weight of approximately 83 kDa. It is expressed widely across various tissues with notable presence in the liver adrenal glands and reproductive organs. This enzyme resides within the endoplasmic reticulum membrane reflecting its involvement in cholesterol synthesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLSS catalyzes an important step in the conversion of squalene a precursor to the steroid skeleton into lanosterol. This function places LSS as an important contributor in the cholesterol biosynthesis pathway. LSS forms part of the sterol biosynthesis complex interacting with other enzymes to facilitate the production of essential sterols. By producing lanosterol LSS acts as a precursor gateway for other steroid hormones and molecules.\u003cbr\u003e\nPathways\u003cbr\u003e\nCholesterol homeostasis and steroidogenesis heavily depend on LSS activity. The enzyme operates within the mevalonate pathway an important cholesterol-producing route and is essential for the synthesis of isoprenoids. It interacts closely with HMG-CoA reductase an important regulator of cholesterol levels highlighting its central role in maintaining cellular lipid balance. Through its enzymatic action LSS links the synthesis of cholesterol with downstream steroid hormones.\u003cbr\u003e\nLSS has associations with conditions such as lathosterolosis a rare autosomal recessive disorder affecting cholesterol biosynthesis. Mutations in the LSS gene disrupt normal cholesterol production contributing to developmental abnormalities. Additionally LSS has connections to hypercholesterolemia having indirect relations through the cholesterol metabolism pathway which also involves the LDL receptor. These dysfunctions highlight the importance of LSS in maintaining systemic lipid homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851098771625,"sku":"ab248887","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248887","provider":"Iright","version":"1.0","type":"link"}