{"product_id":"abcam-ab248951","title":"Abcam, ab248951, Anti-EG-VEGF antibody [EPR9699] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal EG-VEGF antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9699,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248951 is the carrier-free version of\u003cbr\u003e\nab150375\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEG-VEGF also known as endocrine gland-derived vascular endothelial growth factor or prokineticin 1 is a potent angiogenic mitogen. It typically has a molecular mass of around 9 kDa. EG-VEGF is expressed mainly in steroidogenic tissues such as the ovaries testes adrenal glands and placenta. It targets endothelial cells selectively within these glands inducing various responses like proliferation migration and fenestration. This selectivity makes it distinct from vascular endothelial growth factor A (VEGF-A) which has a broader expression pattern.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEG-VEGF plays a critical role in the formation and remodeling of blood vessels specific to endocrine glands. It is not part of a larger protein complex but operates through interaction with its receptor prokineticin receptor 1 (PROKR1). This unique interaction means that it has a specific ligand-receptor activity contributing to the regulation of vascular development especially in tissues undergoing hormonal changes. This makes EG-VEGF significant in contexts where localized and specific angiogenesis is essential.\u003cbr\u003e\nPathways\u003cbr\u003e\nEG-VEGF is important in the regulation of angiogenesis and endothelial function. It fits into pathways that influence cell signaling associated with vascular development. One such pathway is the hypoxia-inducible factor (HIF) pathway which enhances the expression of EG-VEGF under low oxygen conditions. Another related protein is vascular endothelial growth factor (VEGF) whereby VEGF and EG-VEGF demonstrate distinctive yet occasionally overlapping functions in angiogenesis optimizing vascular growth within specific environments.\u003cbr\u003e\nEG-VEGF shows associations with conditions like preeclampsia and polycystic ovary syndrome (PCOS). Preeclampsia involves improper vascularization in the placenta where EG-VEGF's role in angiogenesis becomes critical as it may help or disrupt proper vascular development. Polycystic ovary syndrome a hormonal disorder impacting ovaries also links with EG-VEGF through its effect on ovarian blood vessels. These disorders highlight potential therapeutic targets considering EG-VEGF’s integration with other proteins like PROKR1 which could modulate its angiogenic functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851270344873,"sku":"ab248951","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248951","provider":"Iright","version":"1.0","type":"link"}