{"product_id":"abcam-ab248954","title":"Abcam, ab248954, Anti-Desmocollin 1 antibody [EPR8220] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Desmocollin 1 antibody. Carrier free. Suitable for WB and reacts with Human, Transfected cell lysate, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8220,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248954 is the carrier-free version of\u003cbr\u003e\nab150382\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDesmocollin 1 also known as DSC1 belongs to the desmocollin subfamily of cadherin proteins. It acts mechanically by facilitating cell-cell adhesion within epithelial tissue. DSC1 is a desmosomal cadherin playing a fundamental role in maintaining the structural integrity of tissues that undergo mechanical stress. This protein displays an approximate specific mass of 100 kDa. Its expression typically localizes to the suprabasal layers of stratified squamous epithelia such as the skin.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDesmocollin 1 contributes by linking the extracellular matrix with the cellular cytoskeleton through desmosomal plaques. It takes part in desmosome complexes by partnering with other cadherins including desmogleins and linker proteins like plakoglobin and plakophilins. This linkage strengthens adhesion between keratinocytes which enhances the resilience of epithelial barriers.\u003cbr\u003e\nPathways\u003cbr\u003e\nDesmocollin 1 plays an important role in the regulation of cell adhesion pathways and intracellular signaling. It interacts within the desmosome assembly pathway which is responsible for forming stable cell-cell junctions. Another related pathway includes the signal transduction pathways where desmocollin 1 associates with proteins like plakoglobin which links desmosomes to cytoplasmic signaling networks that can influence cell behavior.\u003cbr\u003e\nDesmocollin 1 connects mainly to skin-related issues like pemphigus foliaceus and certain types of skin carcinomas. Pemphigus foliaceus involves autoantibodies targeting components of the desmosome like desmogleins disrupting desmocollin 1's adhesion role leading to blistering. In skin carcinomas alterations in the expression or function of desmocollin 1 may lead to structural integrity loss contributing to cancer invasion. Understanding these associations helps in developing therapeutic strategies targeting the interplay between desmocollin 1 and associated proteins within affected tissues.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852393205929,"sku":"ab248954","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab248954","provider":"Iright","version":"1.0","type":"link"}