{"product_id":"abcam-ab249013","title":"Abcam, ab249013, Anti-SH3KBP1 antibody [EPR7881(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SH3KBP1 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7881(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249013 is the carrier-free version of\u003cbr\u003e\nab151574\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe SH3 domain-containing kinase-binding protein 1 (SH3KBP1) also known as Cin85 is a multifunctional adapter protein involved in signal transduction pathways. It has a molecular mass of approximately 85 kDa. SH3KBP1 is expressed in a variety of tissues including the brain heart and lungs reflecting its diverse roles in cellular processes. This protein contains multiple SH3 domains that facilitate the binding with other proteins making SH3KBP1 an important modulator of protein-protein interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSH3KBP1 plays a role in cellular signaling and endocytosis. It forms part of a complex that participates in the regulation of membrane trafficking where it helps in internalization and down-regulation of receptor tyrosine kinases. SH3KBP1 interacts with other signaling molecules allowing it to coordinate the spatial and temporal dynamics of signaling pathways. This protein’s involvement in endocytic pathways highlights its significance in regulating cellular responses to external stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nSH3KBP1 is an integral part of the epidermal growth factor receptor (EGFR) signaling and the B-cell receptor (BCR) signaling pathways. In the EGFR pathway it facilitates receptor internalization affecting processes such as proliferation and survival. SH3KBP1 interacts with proteins like c-Cbl and Grb2 which are key players in receptor endocytosis and signal transduction. Through these interactions it modulates signal cascades that influence numerous cellular outcomes.\u003cbr\u003e\nSH3KBP1 is implicated in cancer and autoimmune diseases. Its role in EGFR signaling connects it to cancer progression as dysregulation of this pathway can lead to uncontrolled cell growth. In autoimmune diseases SH3KBP1's interaction with BCR signaling components including CD19 and Syk can affect immune cell function and lead to pathological immune responses. Understanding the role of SH3KBP1 in these contexts can inform therapeutic strategies targeting its pathway involvement.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851826843817,"sku":"ab249013","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249013","provider":"Iright","version":"1.0","type":"link"}