{"product_id":"abcam-ab249015","title":"Abcam, ab249015, Anti-OSBPL9 antibody [EPR9333] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal OSBPL9 antibody. Carrier free. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9333,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249015 is the carrier-free version of\u003cbr\u003e\nab151691\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOSBPL9 also referred to as oxysterol-binding protein-like 9 is a member of the oxysterol-binding protein (OSBP)-related protein family. This protein family involves intracellular lipid transport. OSBPL9 has a molecular weight of approximately 89 kDa. It is expressed in various tissues with high levels in brain pancreas and intestine. The protein possesses a pleckstrin homology domain and a conserved OSBP-related domain which play roles in binding to lipids and facilitating their transport within cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOSBPL9 participates in lipid metabolism and cellular lipid homeostasis. It binds to phosphoinositides and sterols regulating lipid distribution and signaling. Studies indicate that OSBPL9 forms part of a complex involved in the transfer of lipids at the membrane contact sites between organelles such as the endoplasmic reticulum and the Golgi apparatus. These interactions highlight its integral role in maintaining lipid equilibrium across cellular compartments.\u003cbr\u003e\nPathways\u003cbr\u003e\nA deeper understanding of OSBPL9 shows its involvement in signaling pathways alongside other lipid-binding proteins. It plays a significant role within the sterol regulatory element-binding protein (SREBP) signaling pathway and potentially the PI3K-Akt signaling pathway. These pathways are essential in lipid synthesis and cellular growth. OSBPL9 shares functional interactions with proteins like OSBP and other OSBP-related proteins emphasizing its collaborative involvement in these pathways.\u003cbr\u003e\nOSBPL9 association with dyslipidemia and metabolic disorders has been observed due to its influence on lipid homeostasis. Alterations in OSBPL9 function may contribute to abnormal lipid levels impacting conditions like atherosclerosis. The protein's connection to metabolic pathways suggests a linkage with proteins such as OSBPL10 further indicating its potential involvement in the pathogenesis of these metabolic disorders. Researchers continue to study OSBPL9 to better understand its role in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860397871273,"sku":"ab249015","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249015","provider":"Iright","version":"1.0","type":"link"}