{"product_id":"abcam-ab249024","title":"Abcam, ab249024, Anti-TMF antibody [EPR10671(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TMF antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10671(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249024 is the carrier-free version of\u003cbr\u003e\nab151702\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTranscriptional mediator factor (TMF) also known as TMF\/ARA160 weighs around 160 kDa. It resides in the nucleus and cytoplasm of cells. TMF is a multifunctional protein and plays a part in transcription regulation. It interacts with protein complexes influencing their stability and function. In addition to its nuclear roles TMF associates with the Golgi apparatus suggesting its diverse function in different cellular contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of TMF extends to various cellular processes including transcriptional regulation signal transduction and vesicle transport. It forms part of larger protein complexes which modulate gene expression and cellular signaling networks. TMF serves as a scaffold facilitating the interactions between transcription factors and other regulatory proteins. This makes TMF an active regulator of transcriptional control impacting gene expression patterns.\u003cbr\u003e\nPathways\u003cbr\u003e\nMany known cellular pathways require TMF's involvement. TMF impacts the NF-kappaB signaling pathway and the Wnt signaling pathway. It directly interacts with proteins like RelA in the NF-kappaB pathway where it modulates transcriptional activation. TMF's influence on these pathways highlights its significant role in regulating cellular responses and maintaining cellular homeostasis.\u003cbr\u003e\nResearch shows that TMF has associations with cancer and neurodegenerative diseases. Its abnormal expression or mutation links to tumorigenesis particularly in cancers such as prostate and breast cancer. Its interaction with proteins such as beta-catenin in the Wnt pathway associates TMF with oncogenic processes. Moreover TMF's role in the Golgi apparatus links it to neurodegenerative disorders where disruptions in vesicle transport are common features.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851833397417,"sku":"ab249024","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249024","provider":"Iright","version":"1.0","type":"link"}